Search on: PPTB 
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Descriptor English:   Polypyrimidine Tract-Binding Protein 
Descriptor Spanish:   Proteína de Unión al Tracto de Polipirimidina 
Descriptor Portuguese:   Proteína de Ligação a Regiões Ricas em Polipirimidinas 
Synonyms English:   PTB Protein
PTB Splicing Factor
Polypyrimidine Tract Binding Protein
Splicing Factor, PTB
Tract-Binding Protein, Polypyrimidine
p57 Cytoplasmic RNA Binding Protein
p57 Cytoplasmic RNA-Binding Protein
pPTB  
Tree Number:   D12.776.157.725.829.250
D12.776.664.962.829.250
Definition English:   A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product. 
History Note English:   2003; use POLYPYRIMIDINE TRACT-BINDING PROTEIN (NM) 1991-2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   37409 
Unique Identifier:   D038941 

Occurrence in VHL:
 

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