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DeCS
Descriptor
English
:
Simvastatin
Descriptor
Spanish
:
Simvastatina
Descriptor
Portuguese
:
Sinvastatina
Synonyms
English
:
MK 733
MK-733
MK733
Synvinolin
Zocor
Tree Number:
D02.455.426.559.847.638.400.900
D04.615.638.400.900
Definition
English
:
A derivative of
LOVASTATIN
and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl
coenzyme A
reductase (
HYDROXYMETHYLGLUTARYL COA REDUCTASES
), which is the rate-limiting enzyme in
cholesterol
biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL
CHOLESTEROL.
Pharmacological Action:
Anticholesteremic Agents
Hypolipidemic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
See Related
English
:
Rosuvastatin Calcium
History Note
English
:
98; use SIMVASTATIN (NM) 1986-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33420
Unique Identifier:
D019821
Occurrence in VHL
:
Similar:
DeCS