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DeCS
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Descriptor English:
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Trimetrexate
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Descriptor Spanish:
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Trimetrexato
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Descriptor Portuguese:
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Trimetrexato
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Synonyms English:
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CI 898
CI-898
CI898
Hydrate, Trimetrexate
JB 11
JB-11
JB11
Monohydrate, Monoacetate Trimetrexate
NSC 249008
NSC 328564
NSC-249008
NSC-328564
NSC249008
NSC328564
Trimetrexate Hydrate
Trimetrexate Monohydrate, Monoacetate
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Tree Number:
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D03.633.100.786.925
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Definition English:
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A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect. |
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Pharmacological Action:
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Antifungal Agents
Antimetabolites, Antineoplastic
Folic Acid Antagonists
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History Note English:
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92; was TRIMETREXATE (NM) 1979-91
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Allowable Qualifiers English:
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Record Number:
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29766
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Unique Identifier:
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D016597
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Occurrence in VHL:
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Similar:
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DeCS
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