|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Cisplatin
|
|
Descriptor Spanish:
|
|
Cisplatino
|
|
Descriptor Portuguese:
|
|
Cisplatino
|
|
Synonyms English:
|
|
Biocisplatinum
Diamminodichloride, Platinum
Dichlorodiammineplatinum
NSC-119875
Platidiam
Platino
Platinol
Platinum Diamminodichloride
cis Diamminedichloroplatinum
cis Platinum
cis-Diamminedichloroplatinum
cis-Diamminedichloroplatinum(II)
cis-Dichlorodiammineplatinum(II)
cis-Platinum
|
|
Tree Number:
|
|
D01.210.375
D01.625.125
D01.710.100
|
|
Definition English:
|
|
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. |
|
Pharmacological Action:
|
|
Antineoplastic Agents
Cross-Linking Reagents
Radiation-Sensitizing Agents
|
|
History Note English:
|
|
84(81); was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
2971
|
|
Unique Identifier:
|
|
D002945
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|