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BOTULIN
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DeCS
Descriptor
English
:
Botulinum Toxins
Descriptor
Spanish
:
Toxinas Botulínicas
Descriptor
Portuguese
:
Toxinas Botulínicas
Synonyms
English
:
Botulin
Botulinum Toxin
Clostridium botulinum Toxins
Toxin, Botulinum
Toxins, Botulinum
Toxins, Clostridium botulinum
Tree Number:
D08.811.277.656.300.480.153
D08.811.277.656.675.374.153
D12.776.097.156
D23.946.123.179
Definition
English
:
Toxic
proteins
produced from the species
CLOSTRIDIUM BOTULINUM
. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The
botulinum
toxin light chain is a zinc-dependent protease which is released from the heavy chain upon
ENDOCYTOSIS
into PRESYNAPTIC
NERVE ENDINGS
. Once inside the cell the
botulinum
toxin light chain cleaves specific
SNARE proteins
which are essential for secretion of
ACETYLCHOLINE
by
SYNAPTIC VESICLES
. This inhibition of
acetylcholine
release results in muscular
PARALYSIS.
Indexing Annotation
English
:
/antag permitted but consider also
BOTULINUM ANTITOXIN
Pharmacological Action:
Neurotoxins
Acetylcholine Release Inhibitors
See Related
English
:
Botulism
History Note
English
:
78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
1930
Unique Identifier:
D001905
Occurrence in VHL
:
Similar:
DeCS