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DeCS
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Descriptor English:
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Apoptosomes
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Descriptor Spanish:
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Apoptosomas
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Descriptor Portuguese:
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Apoptossomas
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Synonyms English:
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Apoptosomal Protein Complex
Apoptosome
Complex, Apoptosomal Protein
Protein Complex, Apoptosomal
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Tree Number:
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D05.500.099
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Definition English:
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Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9. |
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History Note English:
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2007
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Allowable Qualifiers English:
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Record Number:
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52179
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Unique Identifier:
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D053478
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Occurrence in VHL:
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Similar:
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DeCS
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