1 / 1
|
DeCS
|
|
|
Descriptor English:
|
|
X-linked Nuclear Protein
|
Descriptor Spanish:
|
|
Proteína Nuclear Ligada al Cromosoma X
|
Descriptor Portuguese:
|
|
Proteína Nuclear Ligada ao X
|
Synonyms English:
|
|
ATRX Protein
Homolog Protein, RAD54
Nuclear Protein, X-linked
RAD54 Homolog Protein
X linked Nuclear Protein
|
Tree Number:
|
|
D08.811.399.340.375
|
Definition English:
|
|
ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome). |
See Related English:
|
|
PHD Zinc Fingers
|
History Note English:
|
|
2018
|
Allowable Qualifiers English:
|
|
|
Record Number:
|
|
57010
|
Unique Identifier:
|
|
D000075924
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|