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STAT (SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION) PROTEINS
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DeCS
Descriptor
English
:
STAT Transcription Factors
Descriptor
Spanish
:
Factores de Transcripción STAT
Descriptor
Portuguese
:
Fatores de Transcrição STAT
Synonyms
English
:
STAT (Signal Transducers and Activators of Transcription) Proteins
Transcription Factors, STAT
Tree Number:
D12.644.360.024.342
D12.776.157.057.186
D12.776.476.024.430
D12.776.930.840
Definition
English
:
A
family
of
transcription factors
containing SH2 DOMAINS that are involved in CYTOKINE-mediated
SIGNAL TRANSDUCTION
.
STAT transcription factors
are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via
PHOSPHORYLATION
. Once activated they dimerize and translocate into the
CELL NUCLEUS
where they influence
GENE expression
. They play a role in regulating
CELL GROWTH PROCESSES
and
CELL DIFFERENTIATION
.
STAT transcription factors
are inhibited by
SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS
and
PROTEIN INHIBITORS OF ACTIVATED STAT.
Indexing Annotation
English
:
general; prefer specifics
History Note
English
:
2006
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50795
Unique Identifier:
D050791
Occurrence in VHL
:
Similar:
DeCS