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DeCS
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Descriptor English:
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Dideoxynucleosides
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Descriptor Spanish:
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Didesoxinucleósidos
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Descriptor Portuguese:
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Didesoxinucleosídeos
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Synonyms English:
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2',3' Dideoxynucleosides
2',3'-Dideoxynucleosides
Dideoxyribonucleosides
ddNus
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Tree Number:
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D13.570.230.500
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Definition English:
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Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription. |
Indexing Annotation English:
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antivirals & antimetabolites
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Pharmacological Action:
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Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors
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History Note English:
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89
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Allowable Qualifiers English:
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Record Number:
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23607
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Unique Identifier:
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D015224
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Occurrence in VHL:
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Similar:
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DeCS
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