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DeCS
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Descriptor English:
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Debrisoquin
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Descriptor Spanish:
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Debrisoquina
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Descriptor Portuguese:
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Debrisoquina
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Synonyms English:
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Debrisoquine
Tendor
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Tree Number:
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D03.633.100.531.205
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Definition English:
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An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. |
Pharmacological Action:
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Antihypertensive Agents
Sympatholytics
Adrenergic Agents
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History Note English:
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91(73); was see under ISOQUINOLINES 1973-90
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Allowable Qualifiers English:
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Record Number:
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3665
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Unique Identifier:
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D003647
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Occurrence in VHL:
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Similar:
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DeCS
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