Search on:
APAF-1 PROTEASE-ACTIVATING FACTOR
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Apoptotic Protease-Activating Factor 1
Descriptor
Spanish
:
Factor Apoptótico 1 Activador de Proteasas
Descriptor
Portuguese
:
Fator Apoptótico 1 Ativador de Proteases
Synonyms
English
:
Apaf 1 Protease Activating Factor
Apaf-1 Protease-Activating Factor
Apoptotic Peptidase Activating Factor 1
Apoptotic Protease Activating Factor 1
Protease-Activating Factor, Apaf-1
Tree Number:
D12.644.360.024.131.124
D12.644.360.075.358.124
D12.776.157.057.006.124
D12.776.476.024.139.124
D12.776.476.075.358.124
Definition
English
:
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal
WD40 REPEATS
. It plays a role in the mitochondria-stimulated
apoptosis
(
APOPTOSIS
, INTRINSIC PATHWAY) and binds to
CYTOCHROME
C in the
CYTOSOL
to form an APOPTOSOMAL PROTEIN COMPLEX which activates
INITIATOR CASPASES
such as
CASPASE 9.
History Note
English
:
2007(1997)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52304
Unique Identifier:
D053477
Occurrence in VHL
:
Similar:
DeCS