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ALKALOIDS, HYDROGENATED ERGOT
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DeCS
Descriptor
English
:
Dihydroergotoxine
Descriptor
Spanish
:
Dihidroergotoxina
Descriptor
Portuguese
:
Di-Hidroergotoxina
Synonyms
English
:
Alkaloids, Hydrogenated Ergot
Co-Dergocrine
Dihydroergotoxin
Ergot Alkaloids, Hydrogenated
Hydrogenated Ergot Alkaloids
Tree Number:
D03.132.327.412.250
D03.633.400.562.400
Definition
English
:
A mixture of three different hydrogenated derivatives of
ERGOTAMINE
:
DIHYDROERGOCORNINE
;
DIHYDROERGOCRISTINE
; and
DIHYDROERGOCRYPTINE
.
Dihydroergotoxine
has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a
dopamine
agonist. The methanesulfonate salts of this mixture of
alkaloids
are called
ERGOLOID MESYLATES.
Pharmacological Action:
Adrenergic alpha-Antagonists
Dopamine Agonists
See Related
English
:
Dihydroergocornine
Dihydroergocristine
Dihydroergocryptine
History Note
English
:
1977(1975); for ERGOT ALKALOIDS, HYDROGENATED use ERGOLOID MESYLATES 1992-2001
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
4128
Unique Identifier:
D004088
Occurrence in VHL
:
Similar:
DeCS