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ACID, 3-HYDROXY-3-METHYLGLUTARIC
Descriptors Found:
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DeCS
Descriptor
English
:
Meglutol
Descriptor
Spanish
:
Meglutol
Descriptor
Portuguese
:
Meglutol
Synonyms
English
:
3 Hydroxy 3 methylglutaric Acid
3 Hydroxy 3 methylpentanedioic Acid
3-Hydroxy-3-methylglutaric Acid
3-Hydroxy-3-methylpentanedioic Acid
Acid, 3-Hydroxy-3-methylglutaric
Acid, 3-Hydroxy-3-methylpentanedioic
beta Hydroxy beta Methylglutarate
beta-Hydroxy-beta-Methylglutarate
Tree Number:
D02.241.081.337.351.550
Definition
English
:
An antilipemic agent which lowers
cholesterol
,
triglycerides
, serum beta-lipoproteins and
phospholipids
. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl
coenzyme A
as well as inhibiting the activity of
HYDROXYMETHYLGLUTARYL COA REDUCTASES
which is the rate limiting enzyme in the biosynthesis of
cholesterol.
Pharmacological Action:
Anticholesteremic Agents
Hypolipidemic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
History Note
English
:
96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
7073
Unique Identifier:
D015093
Occurrence in VHL
:
Similar:
DeCS