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MFN=57770
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DeCS
Descritor
Inglês
:
Tolcapone
Descritor
Espanhol
:
Tolcapona
Descritor
Português
:
Tolcapona
Sinônimos
Inglês
:
3,4 Dihydroxy 5' methyl 5 nitrobenzophenone
3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone
Ro 40 7592
Ro 40-7592
Ro 407592
Ro-40-7592
Ro407592
SOM0226
Tasmar
Categoria:
D02.455.426.559.389.134.875
D02.455.426.559.389.657.566.845
D02.522.223.875
D02.640.743.845
Definição
Inglês
:
A benzophenone and nitrophenol compound that acts as an inhibitor of
CATECHOL O-METHYLTRANSFERASE
, an enzyme involved in the
metabolism
of
DOPAMINE
and
LEVODOPA
. It is used in the treatment of
PARKINSON DISEASE
in
patients
for whom
levodopa
is ineffective or contraindicated.
Ação Farmacológica:
Antiparkinson Agents
Catechol O-Methyltransferase Inhibitors
Nota Histórica
Inglês
:
2019 (1990)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Número do Registro:
57770
Identificador Único:
D000077867
Ocorrência na BVS
:
Similar:
DeCS