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DeCS
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Descritor Inglês:
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CRISPR-Associated Protein 9
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Descritor Espanhol:
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Proteína 9 Asociada a CRISPR
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Descritor Português:
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Proteína 9 Associada à CRISPR
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Sinônimos Inglês:
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CRISPR Associated Protein 9
Cas9 Endonuclease
Cas9 Enzyme
Cas9 Protein
Endonuclease, Cas9
Enzyme, Cas9
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Categoria:
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D08.811.277.352.355.325.150
D12.776.097.219
D12.776.212.500
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Definição Inglês:
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An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9. |
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Relacionados Inglês:
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CRISPR-Cas Systems
Gene Editing
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Nota Histórica Inglês:
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2019
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Qualificadores Permitidos Inglês:
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Número do Registro:
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57498
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Identificador Único:
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D000076987
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Ocorrência na BVS:
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Similar:
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DeCS
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