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DeCS
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Descriptor English:
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NADPH Oxidases
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Descriptor Spanish:
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NADPH Oxidasas
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Descriptor Portuguese:
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NADPH Oxidases
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Synonyms English:
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NAD(P)H Oxidases
NAD(P)H oxidase
NADPH Oxidase
Nox Proteins
Oxidase, NADPH
Oxidases, NADPH
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Tree Number:
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D08.811.682.608.575
D12.776.331.894
D12.776.543.653
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Definition English:
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A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC. |
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See Related English:
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Granulomatous Disease, Chronic
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History Note English:
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2018 (1997)
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Allowable Qualifiers English:
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Record Number:
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33021
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Unique Identifier:
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D019255
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Occurrence in VHL:
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Similar:
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DeCS
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