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MFN=32846
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DeCS
Descriptor
English
:
CD40 Antigens
Descriptor
Spanish
:
Antígenos CD40
Descriptor
Portuguese
:
Antígenos CD40
Synonyms
English
:
Antigen, CD40
Antigen, CDw40
Antigens, CD40
CD40 Antigen
CDw40 Antigen
Receptor, TNFRSF5
TNFRSF5 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 5
Tree Number:
D12.776.543.750.705.852.760.097
D23.050.301.264.051.140
D23.101.100.150.140
Definition
English
:
Members of the tumor
necrosis
factor receptor superfamily with specificity for
CD40 LIGAND
. They are found on mature
B-LYMPHOCYTES
, some
EPITHELIAL CELLS
; and lymphoid
DENDRITIC CELLS
. Evidence suggests that CD40-dependent activation of B-cells is important for generation of
memory
B-cells within the germinal centers.
Mutations
in the CD40
antigen
gene result in
HYPER-IGM IMMUNODEFICIENCY SYNDROME
, TYPE 3. Signaling of the receptor occurs through its
association
with TNF RECEPTOR-ASSOCIATED FACTORS.
See Related
English
:
CD40 Ligand
History Note
English
:
2018 (1988)
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
32846
Unique Identifier:
D019013
Occurrence in VHL
:
Similar:
DeCS