Search on: MFN=31626 
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Descriptor English:   B7-1 Antigen 
Descriptor Spanish:   Antígeno B7-1 
Descriptor Portuguese:   Antígeno B7-1 
Synonyms English:   Antigen, B7 1
Antigen, B7-1
Antigens, CD80
B Cell Activation Antigen
B-Cell Activation Antigen
B7 1 Antigen
B7 1 Costimulatory Molecule
B7 1 Ligand
B7-1 Costimulatory Molecule
B7-1 Ligand
CD80 Antigen
CD80 Antigens
Costimulatory Molecule, B7-1
Ligand, B7-1  
Tree Number:   D12.776.467.150.100
D12.776.543.095.100
D23.050.301.285.100
D23.529.168.100
Definition English:   A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. 
History Note English:   2018 (1991) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   31626 
Unique Identifier:   D018122 

Occurrence in VHL: 		 

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