Search on: ZALCITABINE 
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Descriptor English:   Zalcitabine 
Descriptor Spanish:   Zalcitabina 
Descriptor Portuguese:   Zalcitabina 
Synonyms English:   2',3' Dideoxycytidine
2',3'-Dideoxycytidine
Dideoxycytidine
HIVID Roche
Hivid
NSC 606170
NSC-606170
NSC606170
ddC (Antiviral)  
Tree Number:   D03.383.742.680.245.500.950
D13.570.230.329.950
D13.570.230.500.925
D13.570.685.245.500.950
Definition English:   A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. 
Pharmacological Action:   Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
 
History Note English:   94; was DIDEOXYCYTIDINE 1990-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   31821 
Unique Identifier:   D016047 

Occurrence in VHL:
 

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