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CILASTATIN, IMIPENEM DRUG COMBINATION
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DeCS
Descriptor
English
:
Cilastatin, Imipenem Drug Combination
Descriptor
Spanish
:
Combinación Cilastatina e Imipenem
Descriptor
Portuguese
:
Combinação Imipenem e Cilastatina
Synonyms
English
:
Cilastatin, Imipenem
Imipenem - Cilastatin
Imipenem - Cilastatin Sodium
Imipenem Cilastatin
Imipenem Cilastatin Sodium
Imipenem Cilastatin, Sodium Salt
Imipenem-Cilastatin
Imipenem-Cilastatin Sodium
Imipenem-Cilastatin, Sodium Salt
MK 0787 MK 0791 mixture
MK 0787-MK 0791 mixture
MK 787 MK 791 mixture
MK 787-MK 791 mixture
Primaxin
Thienam
Tienam 500
Zienam
Tree Number:
D02.065.589.099.124.300.500.500
D02.455.426.392.368.533.200.500
D03.633.100.300.124.300.500.500
D10.251.355.325.200.500
D26.310.356
Definition
English
:
Combination of
imipenem
and
cilastatin
that is used in the treatment of
bacterial infections
;
cilastatin
inhibits renal dehydropeptidase I to prolong the
half-life
and increase the
tissue
penetration of
imipenem
, enhancing its
efficacy
as an anti-bacterial agent.
Pharmacological Action:
Anti-Bacterial Agents
Protease Inhibitors
History Note
English
:
2019 (1985)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
57735
Unique Identifier:
D000077728
Occurrence in VHL
:
Similar:
DeCS