Search on:
CILASTATIN
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Cilastatin
Descriptor
Spanish
:
Cilastatina
Descriptor
Portuguese
:
Cilastatina
Synonyms
English
:
Cilastatin Monosodium Salt
Cilastatin Sodium
MK 0791
MK 791
MK-791
MK0791
MK791
Monosodium Salt, Cilastatin
Salt, Cilastatin Monosodium
Sodium, Cilastatin
Tree Number:
D02.455.426.392.368.533.200
D10.251.355.325.200
Definition
English
:
A renal dehydropeptidase-I and
leukotriene D4
dipeptidase inhibitor. Since the antibiotic,
IMIPENEM
, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule,
cilastatin
is administered with
imipenem
to increase its
effectiveness
. The drug also inhibits the
metabolism
of
leukotriene D4
to
leukotriene E4.
Pharmacological Action:
Protease Inhibitors
History Note
English
:
89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
23589
Unique Identifier:
D015377
Occurrence in VHL
:
Similar:
DeCS