Search on: 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE 
Descriptors Found: 1
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Descriptor English:   Zidovudine 
Descriptor Spanish:   Zidovudina 
Descriptor Portuguese:   Zidovudina 
Synonyms English:   3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
AZT (Antiviral)
AZT Antiviral
AZT, Antiviral
Antiviral AZT
Azidothymidine
BW A509U
BWA 509U
BWA-509U
BWA509U
Retrovir  
Tree Number:   D03.383.742.680.705.950
D13.570.230.500.950
D13.570.230.855.950
D13.570.685.705.950
Definition English:   A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. 
Pharmacological Action:   Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
 
History Note English:   89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   23867 
Unique Identifier:   D015215 

Occurrence in VHL:
 

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