Search on: 12-LIPOXYGENASE 
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Descriptor English:   Arachidonate 12-Lipoxygenase 
Descriptor Spanish:   Araquidonato 12-Lipooxigenasa 
Descriptor Portuguese:   Araquidonato 12-Lipoxigenase 
Synonyms English:   12 Lipoxygenase
12-Lipoxygenase
12-Lipoxygenase, Arachidonate
12-Lipoxygenase, Arachidonic Acid
Arachidonate 12 Lipoxygenase
Arachidonic Acid 12 Lipoxygenase
Arachidonic Acid 12-Lipoxygenase  
Tree Number:   D08.811.682.690.416.583.500.060
D12.776.556.579.374.568.500.025
Definition English:   An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS. 
Entry Combination - descr/qualif English:   Arachidonate 12-Lipoxygenase/antagonists & inhibitors use Lipoxygenase Inhibitors
 
History Note English:   91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   19075 
Unique Identifier:   D001092 

Occurrence in VHL:
 

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