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ALPHALBETA2, INTEGRIN
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DeCS
Descriptor
English
:
Lymphocyte Function-Associated Antigen-1
Descriptor
Spanish
:
Antígeno-1 Asociado a Función de Linfocito
Descriptor
Portuguese
:
Antígeno-1 Associado à Função Linfocitária
Synonyms
English
:
Antigen-1, Lymphocyte Function-Associated
Integrin alphaLbeta2
LFA-1
Leukocyte Function Associated Antigen-1
Lymphocyte Function Associated Antigen 1
alphaLbeta2, Integrin
Tree Number:
D12.776.395.550.200.074.937
D12.776.395.550.200.625.550
D12.776.543.550.200.093.937
D12.776.543.550.200.625.550
D12.776.543.750.705.408.600.400
D12.776.543.750.705.877.550
D23.050.301.350.074.400
D23.050.301.350.625.550
Definition
English
:
An integrin heterodimer widely expressed on cells of hematopoietic origin.
CD11A ANTIGEN
comprises the alpha chain and the CD18
antigen
(
CD18 ANTIGENS
) the beta chain.
Lymphocyte function-associated antigen-1
is a major receptor of T-CELLS; B-CELLS; and
GRANULOCYTES
. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and
granulocytes
. Intracellular adhesion molecule-1 has been defined as a ligand for
lymphocyte function-associated antigen-1.
History Note
English
:
1991
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29009
Unique Identifier:
D016169
Occurrence in VHL
:
Similar:
DeCS